"Call Me When You're Sober" is a song by American rock band Evanescence from their second studio album, The Open Door. It was released as the album's lead single on September 4, 2006. The track was written by Amy Lee and guitarist Terry Balsamo, and produced by Dave Fortman. A musical fusion of alternative metal, symphonic rock, and electropop, the song was inspired by the end of Lee's relationship with singer Shaun Morgan as well as Lee's other experiences at the time.

"Call Me When You're Sober" peaked at number ten on the US Billboard Hot 100 and number four on the Alternative Songs chart, and entered the top ten of several Billboard component charts. It also peaked within the top ten on multiple international charts, including the UK, Australia, Italy, Canada, and New Zealand. It was certified platinum by the Recording Industry Association of America and gold by the Australian Recording Industry Association. The song received generally positive reception from music critics. Its music video was directed by Marc Webb, and depicts a metaphorical visual, drawing inspiration from the fairy tale "Little Red Riding Hood".